We present FATHMM-XF, a method for predicting pathogenic point mutations in the human genome. Drawing on an extensive feature set, FATHMM-XF outperforms competitors on benchmark tests, particularly in non-coding regions where the majority of pathogenic mutations are likely to be found.

Availability and implementation

The FATHMM-XF web server is available at, and as tracks on the Genome Tolerance Browser: Predictions are provided for human genome version GRCh37/hg19. The data used for this project can be downloaded from:

Supplementary information

Supplementary data are available at Bioinformatics online.

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